Targeted degradation of CTCF decouples local insulation of chromosome domains from higher-order genomic compartmentalization
Journal: Nora EP, Goloborodko A, Valton AL, Gibcus JH, et al. , (). Targeted degradation of CTCF decouples local insulation of chromosome domains from higher-order genomic compartmentalization bioRxiv . ,
Abstract:The molecular mechanisms underlying folding of mammalian chromosomes remain poorly understood. The transcription factor CTCF is a candidate regulator of chromosomal structure. Using the auxin-inducible degron system in mouse embryonic stem cells, we show …
URL: https://www.biorxiv.org/content/early/2017/01/07/095802.abstract
