: an funded by the an nsf expedition in computing an nsf expedition Menu

Multilayer DNA origami packed on hexagonal and hybrid lattices.


Journal:
Ke Y, Voigt NV, Gothelf KV, Shih WM , (). Multilayer DNA origami packed on hexagonal and hybrid lattices. J. Am. Chem. Soc. . 134(3), 1770-4

Abstract:

“Scaffolded DNA origami” has been proven to be a powerful and efficient approach to construct two-dimensional or three-dimensional objects with great complexity. Multilayer DNA origami has been demonstrated with helices packing along either honeycomb-lattice geometry or square-lattice geometry. Here we report successful folding of multilayer DNA origami with helices arranged on a close-packed hexagonal lattice. This arrangement yields a higher density of helical packing and therefore higher resolution of spatial addressing than has been shown previously. We also demonstrate hybrid multilayer DNA origami with honeycomb-lattice, square-lattice, and hexagonal-lattice packing of helices all in one design. The availability of hexagonal close-packing of helices extends our ability to build complex structures using DNA nanotechnology.

read article